Endocrine Abstracts

To analyze the data of relatives of first-degree patients operated on for medullary thyroid cancer (MTC), we analyzed the anamnestic data of the database of patients with MTC, formed on the basis of the cancer registry of the Republic of Belarus and medical records of the Republican Thyroid Tumor Center. Further examination of relatives is also performed on the basis of the Republican Center for Thyroid Tumors.The aim: of the study was to create a databa...

Assessment of basal calcitonin as the main marker of medullary thyroid cancer (MTC) was introduced into routine practice in the Republic of Belarus more than 10 years ago. A number of laboratory and clinical factors can influence the result of this parameter determination. Equally important is the gender, age, weight, the deviation of the serum calcium level, certain medications.The aim: Of the study was to develop and implement of stimulated calcitonin ...

Introduction: The long-term follow-up of the patients with well-differentiated thyroid cancer (WDTC) includes the monitoring of suppressive levothyroxine therapy. Our study evaluated the peculiarities of thyroid status in WDTC patients on the doses of levothyroxine leading to TSH suppression (lower than 0.5 mI/l).Study design: We have studied 114 patients with WDTC, 24 men and 90 women. The follow-up was a least 10 years after thyroid surgery, mean age a...

Background: The recommended method of initial testing for MEN2A is either a single or multi-tiered analysis to detect RET mutations in exon 8, 10, 11, 13, 14, 15, and 16.The aim of the study was to determine the relationship between the aggressiveness of the clinical course of MTC and identified mutations.Materials and methods: The research is carried out of the program ‘To develop and implement effective technologies for the ...

Objective: To study the effect of parathyroidectomy (PTE) on the BMD in postmenopausal women with primary hyperparathyroidism (PHPT).Materials and methods: We studied 38 postmenopausal women with mild PHPT without osteoporosis (T-score ≥ −2,5 by DXA). In 20 patients was performed PTE, the comparison group:18 postmenopausal patients with PHPT. The duration of observation was 1 year. Examination: total calcium, Ca++, phosphorus, PTH,...

Multiple endocrine neoplasia type 2 (MEN2) is a hereditary condition with an autosomal dominant type of inheritance. It is evident that MEN2 is characterized by the presence of Medullary Thyroid Cancer (MTC) as a permanent symptom, the combination of which with pheochromocytoma and parathyroid syndrome is referred to as MEN-2A syndrome. The aim of our study was the creation of a database of patients with MTC and analysis of the data.Materials and methods...

The medical and social significance of the Multiple Endocrine Neoplasia type 2 (MEN2) is due to the severity of the manifestations of the disease components, namely the tumor process progression, a high risk of vascular accidents, pathological fractures of the femoral neck/spine, gastrointestinal bleeding, chronic renal failure. Late detection of pathology is associated with high mortality due to medullary thyroid cancer (MTC). Thus, the aim of the study was to establish the c...

BackgroundThe multiple endocrine neoplasia syndrome type 2 (MEN-2) is characterized by medullary thyroid cancer (MTC) as a permanent feature; the combination with pheochromocytoma and parathyroidism is referred as MEN-2a syndrome. The reason for hereditary forms of MTC is mutations in the proto-oncogene RET (RE-arranged during Transfection).The aim of the study was to establish the molecular determinants frequency of MEN-2 syndrome...

BackgroundMedullary thyroid cancer (MTC) is a calcitonin-producing C-cell tumor and accounts about 5% in the structure of thyroid malignancies. There are sporadic and hereditary variant of MTC, which is a mandatory component of endocrine neoplasia syndrome type 2. The aim of the study was to determine the relationship between the aggressiveness of the clinical course of MTC and demographic characteristics.Materials and methods<...

BackgroundThe management of patients with medullary thyroid cancer (MTC) has an important endocrinological aspect, because MTC can be a manifestation of multiple endocrine neoplasia syndrome (MEN), a genetically determined pathology with an autosomal dominant inheritance. MEN-2 syndrome is characterized by of MTC as a permanent feature, the combination with pheochromocytoma and/or adenoma of the parathyroid glands. The aim of the study was to determine t...